《Nature Medicine》：治疗性克隆能改善鼠帕金森氏症
据最新一期英国《自然—医学》（Nature Medicine）杂志网络版报道，美国斯隆—凯特林癌症研究所研究人员用治疗性克隆技术治疗实验鼠帕金森氏症获得成功。
报道说，研究人员给患帕金森氏症的实验鼠移植了由其自身皮肤细胞克隆产生的神经细胞，后者能产生神经传导物质多巴胺，结果实验鼠的病情出现明显改善。帕金森氏症是一种神经疾病，主要病因是脑中的多巴胺分泌量不足。
研究人员称，这种利用治疗性克隆技术治疗帕金森氏症的疗法前景看好，因为移植的神经细胞来自实验鼠自身，不会被实验鼠的免疫系统排斥。
治疗性克隆即利用克隆技术获取人类早期胚胎，但目的不是将胚胎培育成人，而是为了提取全能型胚胎干细胞，然后在合适的条件下，使其发育成为所需的细胞甚至器官，用于治疗人类疾病。
原文出处：http://www.nature.com/nm/journal/vaop/ncurrent/abs/nm1732.html
Nature Medicine Published online: 23 March 2008 | doi:10.1038/nm1732
Therapeutic cloning in individual parkinsonian mice
Viviane Tabar1,2, Mark Tomishima3,5, Georgia Panagiotakos1,5, Sayaka Wakayama4, Jayanthi Menon1, Bill Chan1, Eiji Mizutani4, George Al-Shamy1, Hiroshi Ohta4, Teruhiko Wakayama4 & Lorenz Studer1,3
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Cell transplantation with embryonic stem (ES) cell progeny requires immunological compatibility with host tissue. 'Therapeutic cloning' is a strategy to overcome this limitation by generating nuclear transfer (nt)ES cells that are genetically matched to an individual. Here we establish the feasibility of treating individual mice via therapeutic cloning. Derivation of 187 ntES cell lines from 24 parkinsonian mice, dopaminergic differentiation, and transplantation into individually matched host mice showed therapeutic efficacy and lack of immunological response.
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1. Department of Neurosurgery, Sloan-Kettering Institute, 1275 York Ave, New York, New York 10065, USA.
2. Department of Neurosurgery, Weill Medical College of Cornell University, 1300 York Ave, New York, New York 10065, USA.
3. Developmental Biology Program, Sloan-Kettering Institute, 1275 York Ave, New York, New York 10065, USA.
4. RIKEN Center for Developmental Biology, 2-2-3 Minatojima-minamimachi, Kobe 650-0047, Japan.
5. These authors contributed equally to this work.
Correspondence to: Viviane Tabar1,2 e-mail: tabarv@mskcc.org
Correspondence to: Lorenz Studer1,3 e-mail: studerl@mskcc.org
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